Workplace exposure to injury is influenced by a variety of factors. These include the state of the equipment in use, the knowledge and skill of the worker, the procedures in place, the organizational culture that encourages some activities and discourages others, and leadership that drives that culture. In order to reduce exposure in a comprehensive and sustainable way, leading organizations are tackling these influential factors by integrating their safety systems with what have traditionally been separate organizational processes. The results of this approach allow these organizations to better address what meaningfully contributes to safety outcomes, and in the process builds a working environment that fosters heightened organizational citizenship and company-wide ownership for safety. This presentation describes how organizations are building these integrated systems, which organizational processes are included, and the various outcomes of this effort.